Pathogenicity & transmission of vNDV from the 2018-19 California outbreak
01.04.2019
Virology 531 (2019) 203-218
Newcastle Disease viruses that are virulent for chickens and cause ND are not commonly isolated in the U.S.
In May of 2018, virulent Newcastle disease virus was detected in sick, backyard, exhibition chickens in southern California. Since, 401 backyard flocks (primarily chicken, two turkey, two mixed species, and one pigeon flocks), 4 commercial laying hens farms, one live bird market, and 2 feeder stores have been confirmed positive for vNDV in California, and one backyard flock in Utah. The pathogenesis and transmission potential of this virus, along with two genetically related and widely studied viruses, chicken/California/2002 and chicken/Belize/2008, were evaluated in both 3-week- and 62-week-old chickens given a low, medium, or high challenge dose (102, 104, 106EID50), oculo-nasal infection. All three viruses were highly virulent causing clinical signs, killing all the chickens in the medium and high dose groups, and efficiently transmitting to contacts.
Read more