Indonesia: Factors associated with case fatality of human H5N1 virus infections
19.08.2008
Research
Indonesia has had the most human cases of highly pathogenic avian influenza A (H5N1) and one of the highest case-fatality rates worldwide.
A recent study, published online Aug 15 in The Lancet includes data from public health investigations and, when available, patients' clinical information. The evaluation covered all confirmed human cases between Jun 22, 2005 to Feb 1, 2008.
Of the 127 patients with confirmed H5N1 infections, 103 (81%) died. Median time to hospitalisation was 6 days (range 1–16). Of the 122 hospitalised patients for whom data were available, 121 (99%) had fever, 107 (88%) cough, and 103 (84%) dyspnoea on reaching hospital. However, for the first 2 days after onset, most had non-specific symptoms; only 31 had both fever and cough, and nine had fever and dyspnoea.
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